[79] In 1927, the Bureau of Chemistry's regulatory powers were reorganized under a new USDA body, the Food, Drug, and Insecticide Administration. [15], Emergency Use Authorization (EUA) is a mechanism that was created to facilitate the availability and use of medical countermeasures, including vaccines and personal protective equipment, during public health emergencies such as the Zika virus epidemic, the Ebola virus epidemic and the COVID-19 pandemic. 0000005389 00000 n [78] The Act applied similar penalties to the interstate marketing of "adulterated" drugs, in which the "standard of strength, quality, or purity" of the active ingredient was not either stated clearly on the label or listed in the United States Pharmacopeia or the National Formulary. This was widely viewed as increasingly important in the face of a major outbreak of the disease in West Africa that began in late March 2014 and ended in June 2016. HitFix: I guess my first question is what was it like watching the episode last night and what were you telling yourself on the screen? [6] In 2008, the FDA began to post employees to foreign countries, including China, India, Costa Rica, Chile, Belgium, and the United Kingdom. And I'm like, Just back off! [15] For example, pharmaceutical firms pay fees to expedite drug reviews. Edit. [34], Unacceptable levels of attrition in the clinical stage of development are driving profound changes in the architecture, design, and analysis of clinical trials also. [75], The FDA has collected a large amount of data through the decades. Am J Transplant. We were getting fewer and fewer. Posts about Lindsey Ogle written by CultureCast-Z. government site. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Prospect of these adaptive designed clinical trials are encouraging. [76][77], Up until the 20th century, there were few federal laws regulating the contents and sale of domestically produced food and pharmaceuticals, with one exception being the short-lived Vaccine Act of 1813. Committee on the Assessment of the US Drug Safety System. If you are finding it hard to stop smoking, QuitNow! The US Food and Drug Administration (FDA) has directed considerable effort towards modernizing its regulatory processes over the past decade to address the challenges in the drug development sector. Berkowitz BA. WebFDAs Critical Path Initiative is intended to improve drug development and reduceuncertainty by applying new scientic tools to the development process. Karsdal MA, Henriksen K, Leeming DJ, Mitchell P, Duffin K, Barascuk N, et al. However, this rule failed to motivate many drug companies to conduct additional pediatric drug trials. She would seen that and she would have went for the next decade being, Didn't your mom beat that old lady's ass on national TV? Paving the critical path: how can clinical pharmacology help achieve the vision? Ha ha! [108], The priority review voucher is a provision of the Food and Drug Administration Amendments Act of 2007, which awards a transferable "priority review voucher" to any company that obtains approval for a treatment for a neglected tropical diseases. [19] First task as enlisted in FDAs Critical Path Opportunity List 2006 is the development of new biomarkers to improve clinical trials and medical therapy. Accessibility Faced with numerous lawsuits, the manufacturer voluntarily withdrew it from the market. RELATED: Stephen Fishbachs Survivor Blog: Is Honesty the Best Policy? I liked Tony. As part of its Critical Path initiative, FDA has joined the National Cancer Institute (NCI), the pharmaceutical industry, and academia in a number of activities that A change to over-the-counter (OTC) status is a separate process, and the drug must be approved through an NDA first. 0000038210 00000 n New drug development is a complex, long and expensive activity. Many OTC drug ingredients had been previously approved prescription drugs now deemed safe enough for use without a medical practitioner's supervision like ibuprofen. Some of the focus areas identified apply equally to the production of generic drugs. Quinlan J, Gaydos B, Maca J, Krams M. Barriers and opportunities for implementation of adaptive designs in pharmaceutical product development. [1], A 2004 white paper of FDA documented that the investment required to launch a new drug in the market had risen by 55%; from $1.1 billion to $1.7 billion, during 20002002 as compared to 19952000. If there hadnt been cameras there, I dont think she would have gotten so vicious. Gutman S, Hackett J. Design of a phase 0 microdosing trial for correlation of platinum-induced DNA damage to chemotherapy outcomes. [79] As a result, the FDA's powers and decisions are carefully monitored by several governmental and non-governmental organizations. Select from premium Lindsey Ogle of the highest quality. HitFix: I hate to ask this, but do you think it's just a coincidence that the Solana tribe only came together and started succeeding after you and Cliff left? Sure, I guess. 0000005175 00000 n Recently, ischemia modified albumin (IMA) has been reported to be a biomarker for myocardial ischemia/infarct, in a conference held in April 2010. Sounding the alarm on the increasing difficulty and unpredictability of medical product development, the report concluded that collective action was needed to modernize scientific and technical tools as well as harness information technology to evaluate and predict the safety, effectiveness, and manufacturability of medical products. Wagner JA, Prince M, Wright EC, Ennis MM, Kochan J, Nunez DJ, et al. In 2004, the US Food and Drug Administration introduced the Critical Path Initiative with the intent of modernizing drug development by incorporating recent scientific advances, such as genomics and advanced imaging technologies, into the process. Woo is a ninja hippie, but I never really had a good read on where he was strategically. Also, an advertisement must contain a "fair balance" between the benefits and the risks (side effects) of a drug. Goodman and Gilmans The pharmacological basis of therapeutics. I'm kidding! This gallery depicts Lindsey Ogle's Survivor career. Biomarkers in pulmonary hypertension. Lindsey and Sarah at Aparri camp. See what Lindsey Ogle will be attending and learn more about the event taking place Sep 23 - 24, 2016 in Bradford Woods, 5040 State Road 67, Martinsville IN, 46151. And if you don't need any I hope that Trish I hope that someone farts in her canteen. Please enable it to take advantage of the complete set of features! Get push notifications with news, features and more. CDRH also conducts limited amounts of direct product testing. I was worried that I would get into a physical confrontation with her, says Ogle, 29. [56], The FDA regulates tobacco products with authority established by the 2009 Family Smoking Prevention and Tobacco Control Act. 0 Profile Searches. 0000002774 00000 n Another key funder early in our development was the state of Arizona through Science Foundation Arizona. Therapeutic dosing for evaluation of pharmacokinetic data: A comparative study. More props to him. This review discusses the various strategies adopted under CPI to decrease attrition rate and stagnation of new drug development, and the challenges and controversies associated with CPI. [86] One of the most important statutes in establishing the modern American pharmaceutical market was the 1984 Drug Price Competition and Patent Term Restoration Act, more commonly known as the "Hatch-Waxman Act" after its chief sponsors. I think that she's an OK person. [4] Moreover, only 2 of 10 marketed drugs return their research and development (R and D) investments. Many resources are invested on, and thus wasted, if candidate products are subsequently found to have unacceptable profiles on human evaluation. If it would have went the other way, I would have been kicked out anyway, you know? The Biomarkers Consortium [homepage on the internet]. Its a very physical game, but I was surprised about the social part. Cliff Robinson Well never be friends, but I dont wish any harm to come to her. It was stated that current stagnation was because the prevalent medical product development path was becoming increasingly challenging, inefficient, and costly. Cosmetic products are not, in general, subject to premarket approval by the FDA unless they make "structure or function claims" that make them into drugs (see Cosmeceutical). [16] A 1991 study showed 32% failure rates in phase I and 75% phase transitional probability from phase I to phase II,[17] while a later study conducted in 2003 by the same authors showed failure rates in phase I to increase to 37% and phase transitional probability from phase I to phase II to decrease to 71%, over a period of 12 years. This article explicates the reasoning behind the Critical Path Initiative and discusses examples of successful consortia. Even so, lots of people keep smoking. I don't even want to tell you! Kick 'em in the face guys! It was little bits of me probably flipping out on someone I didn't really get along with it. [107] This became a major concern of pediatricians as evidence accumulated that the physiological response of children to many drugs differed significantly from those drugs' effects on adults. 0000029573 00000 n Districts are based roughly on the geographic divisions of the Federal court system. At what point does the conversation turn to, Get Jeff Probst.. Adaptation may be made to trial procedure and/or statistical procedure during the conduct of a clinical trial. The Center for Devices and Radiological Health (CDRH) is the branch of the FDA responsible for the premarket approval of all medical devices, as well as overseeing the manufacturing, performance and safety of these devices. Development and Regulation of Drugs. Through these various mechanisms, sponsors can confidently adopt the solutions generated through C-Paths collaborative approach, thus ensuring the continuous optimization of the medical product development process. 2011 Dec 21;306(23):2608-9. doi: 10.1001/jama.2011.1837. Comparative investment on new successful drug launch between 19952000 and 20002002[4], Thus, innovative methods were planned and initiated to target this critical path, so as to bring down cost of development, rate of attrition and stagnation and this initiative was called CPI. FDA is escalating its critical path work because a strong FDA is imperative to moving discoveries from microscope to market. This prompted Food and Drug Administration (FDA) to highlight this problem in a 2004 white paper classified as Critical Path Initiative (CPI) and to initiate steps to target stagnation and rise in attrition rates. Science and Research Special Topics, Recalls, Market Withdrawals and Safety Alerts, Archived information about the Critical Path program, Modernizing Clinical Trial Designs and Strategies, Challenges and Opportunities Report - March 2004. The site is secure. Find the question you want to grade. 150 0 obj <>stream We won that one, too. No. [81] This name was shortened to the Food and Drug Administration (FDA) three years later. This article reviews some of the ways that clinical pharmacologists can lead and implement change in the drug development process and includes a discussion of modelbased, semimechanistic drug development, drug/disease models that facilitate informed clinical trial designs and optimal dosing. Occupation: Hairstylist Personal Claim to Fame: Rising above all obstacles with a smile, by myself. http://www.fda.gov/AboutFDA/WhatWeDo/History/Milestones/default.htm, http://www.fda.gov/AboutFDA/WhatWeDo/History/Milestones/ucm128305.htm, http://www.fda.gov/ScienceResearch/SpecialTopics/CriticalPathInitiative/ucm076689.htm, http://www.xceleron.com/metadot/index.pl?id=3088&isa=DBRow&op=show&dbview_id=3049, http://pharmexec.findpharma.com/pharmexec/article/articleDetail.jsp?id=352793, http://ispy2.org/docs/ISPY2_Press%20Release_3-15-10.pdf. New biologics are required to go through a premarket approval process called a Biologics License Application (BLA), similar to that for drugs. Our ongoing success is due to a combination of public and private support for our vision and there are many supporters responsible for C-Paths formation. Do you regret it?No. Learn more For other uses, see, "FDA-Approved" vs. "FDA-Accepted in Food Processing", Vaccines, blood and tissue products, and biotechnology, Patients' rights to access unapproved drugs. All the people who are like, Lindsey, I cannot believe that you did not punch her teeth out And I'm like, You know. These manufacturers and distributors are not allowed to advertise their products in an adulterated way, and they are responsible for evaluating the safety and labeling of their product. These two factors will considerably reduce the cost and time of drug development. Open-source, precompetitive research collaborations under the aegis of CPI are also a matter of concern. -methylacyl CoA racemase expression as a predictor of disease progression in prostate cancer. [19], The FDA frequently works with other federal agencies, including the Department of Agriculture, the Drug Enforcement Administration, Customs and Border Protection, and the Consumer Product Safety Commission. Take my word for it, she said some truly terrible things. I really want to just calm down, but I knew that as soon as I saw her, it would be right back at it. It's Survivor. You never know what's gonna happen. 0000004631 00000 n HitFix: And are you actually rooting for them? Key FDA Critical Path Activities Under Way in 2007. In 1997, the FDA proposed a rule to require pediatric drug trials from the sponsors of New Drug Applications. Woodcock J, Woosley R. The FDA critical path initiative and its influence on new drug development. [58], The nine new graphic warning labels were announced by the FDA in June 2011 and were scheduled to be required to appear on packaging by September 2012. Edit Profile. [42], In 2014, the FDA added an Ebola treatment being developed by Canadian pharmaceutical company Tekmira to the Fast Track program, but halted the phase 1 trials in July pending the receipt of more information about how the drug works. The FDA subdivides substances that it regulates as food into various categoriesincluding foods, food additives, added substances (man-made substances that are not intentionally introduced into food, but nevertheless end up in it), and dietary supplements. 0000019264 00000 n A 2006 court case, Abigail Alliance v. von Eschenbach, would have forced radical changes in FDA regulation of unapproved drugs. [29] Another limitation is that some compounds dissolve readily at microdose, yielding good absorption characteristics; however, at therapeutic doses, they exhibit limited solubility, and absorption becomes dependent on the rate and extent of dissolution, which cannot be predicted at microdose levels. Benchmark 1: Computational Round Robin #1 was an international effort to assess the state of the art in biomedical computational fluid dynamics. So I separated myself from the situation. Appropriate Dose Selection-How to Optimize Clinical Drug Development. It would have been like playing against the Little Rascals with Cliff. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, prescription and over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, animal foods & feed[3] and veterinary products. HHS Vulnerability Disclosure, Help Its employees, known as Consumer Safety Officers, or more commonly known simply as investigators, inspect production and warehousing facilities, investigate complaints, illnesses, or outbreaks, and review documentation in the case of medical devices, drugs, biological products, and other items where it may be difficult to conduct a physical examination or take a physical sample of the product. A predictive biomarker informs the treatment effect on the clinical endpoint. [38] This is called an Abbreviated New Drug Application (ANDA). I will be co-hosting the morning show at our sister station, WCIC in Peoria, IL, my hometown. The 2006 critical path opportunity list outlined specific key areas of critical path focus identified by FDA experts and the public. Third, has the clinical trial become a totally different clinical trial after the modifications, for addressing the study objectives of the originally planned clinical trial? The Analyses of the accumulating study data are performed at pre-planned time-points within the study, with or without formal statistical hypothesis testing. Food and Drug Administration. [48] But, questions have already been raised about the feasibility of these cross-company precompetitive collaborations and many pitfalls have already been noticed. Tony has been an instrument for chaos all season long. Federal government websites often end in .gov or .mil. Jenna quit to be near her ailing mother. 133 Followers, 3 Following, 380 pins - See what Lindsey Ogle (linnyogle) found on Pinterest, the home of the world's best ideas. The Office of Criminal Investigations was established in 1991 to investigate criminal cases. Quick and reliable electronic data collection would seem to be mandatory for a trial that is dependent on constant updating. (2007; 110th Congress H.R. 2007 Feb;81(2):170-7. doi: 10.1038/sj.clpt.6100045. [103][104] Some of the committee's recommendations were incorporated into drafts of the PDUFA IV amendment, which was signed into law as the Food and Drug Administration Amendments Act of 2007. I have a seven-year-old kid now. Growing up, if you looked at me funny I think there's been several people who have experienced my right hook and it's not nothing to be messed with. Thus, eIND differs from conventional IND in the sense that the NME are introduced firstly in humans in non-pharmacologic doses (phase 0) instead of conventional phase I studies, where NME is given in therapeutic doses. Vioxx was approved by the FDA in 1999 and was initially hoped to be safer than previous NSAIDs, due to its reduced risk of intestinal tract bleeding. This protein was recognized as early as second week post-infection and the test can be developed into a simple serodiagnostic-based kit method. Discover more posts about lindsey-ogle. I like him a lot. 0000039382 00000 n Despite a 70% increase in investment in research and development-related activities, a 40% fall in launch of new chemical entities was seen during 19942004. Moreover, trial subjects are used more efficiently, and fewer subjects are given ineffective compounds, ineffective doses, or doses that are unnecessarily high. [108], An initial attempt by the FDA to address this issue was the 1994 FDA Final Rule on Pediatric Labeling and Extrapolation, which allowed manufacturers to add pediatric labeling information, but required drugs that had not been tested for pediatric safety and efficacy to bear a disclaimer to that effect. Under CPI, FDA is boosting the concept of partnerships with pharmaceutical houses and research organizations to accelerate the development of personalized medicines. endstream endobj 111 0 obj <> endobj 112 0 obj <> endobj 113 0 obj <>/Font<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 114 0 obj <> endobj 115 0 obj <> endobj 116 0 obj <> endobj 117 0 obj <>stream Advances in biomedical research over recent decades have substantially raised expectations 0000019339 00000 n This program requires that manufacturers design and implement periodic assessments of their programs' effectiveness. Critical Path Innovation Meetings (CPIM) Watch a video about the CPIM program The Critical Path Innovation Meeting (CPIM) was developed by CDER to I'm not gonna say, 'I'm so hungry and I'm chilly.' I feel like it's a variable but it is not the reason why. The quoted text from the source indicates "9" but the actual count from the website indicates "14". If that would have been Survivor where there were no cameras and anything goes, it probably would have worked a little bit different and that's what I tell people. New drugs receive extensive scrutiny before FDA approval in a process called a new drug application (NDA). Lindsey Ogle/Gallery < Lindsey Ogle. 85718 Tel: 520-547-3440 Fax: 520-547-3456 C-Path Global Ltd. 33 Sir John Rogersons Dublin 2, Ireland By using this Site or clicking on "I Agree," you consent to the use of cookies. Transplant Therapeutics Consortium-Transforming Drug Development through Collaboration. [33] Over the last 10 years, Xceleron has developed a database which compares PK data at microdose and therapeutic dose levels, which shows that for 25 compounds studied, microdose PK scales to pharmacologic dose in over 80% of cases. The science of drug therapy. [49] These include blood and blood products, vaccines, allergenics, cell and tissue-based products, and gene therapy products. The Sentinel Initiative: A National Strategy for Monitoring Medical Product Safety. [79] The Biologics Control Act of 1902 was put in place after a diphtheria antitoxin derived from tetanus-contaminated serum caused the deaths of thirteen children in St. Louis, Missouri. endstream endobj 120 0 obj <> endobj 121 0 obj [/ICCBased 149 0 R] endobj 122 0 obj <> endobj 123 0 obj <>stream It gives them good TV. If I do this, this is probably gonna be the repercussions. And I'm really glad they didn't show everything. WebIn 2004, the US Food and Drug Administration introduced the Critical Path Initiative with the intent of modernizing drug development by incorporating recent scientific advances, Was quitting on your mind? [5] The agency also has 223 field offices and 13 laboratories located throughout the 50 states, the United States Virgin Islands, and Puerto Rico. In the top right, enter how many points the response earned. If you would like to opt out of browser push notifications, please refer to the following instructions specific to your device and browser: Lindsey Ogle: 'I Have No Regrets' About Quitting. Sched.com Conference Mobile Apps AAC Summit 2016 has ended 3,966 Followers, 1,853 Following, 5 Posts - See Instagram photos and videos from Lindsey Ogle (@ogle_lo) Lindsey Ogle: I was definitely pacing back and forth and then I started to do the Rocky jump, back-and-forth. It was the hardest thing Ive ever done. Jeff Probst hailed this as a strange sort of Survivor first. 110 0 obj <> endobj As of December 2018, the FDA campus has a population of 10,987 employees housed in approximately 3,800,000 square feet (350,000 square metres) of space, divided into ten office and four laboratory buildings. [47] With the launch of CPI, many pharmaceutical companies are also collaborating for precompetitive research. sharing sensitive information, make sure youre on a federal The act extended the patent exclusivity terms of new drugs, and tied those extensions, in part, to the length of the FDA approval process for each individual drug. (2006). Lindsey: I don't know! [92][93] The second wave concerned medical marijuana in the 1990s and 2000s. When the FDA requested Endo Pharmaceuticals on June 8, 2017, to remove oxymorphone hydrochloride from the market, it was the first such request in FDA history. Its time to move on. But quitting is a big step. The ACSH says that companies are required to place a warning note on their products if they have not been tested and that experts in cosmetic ingredient reviews also play a role in monitoring safety through influence on the use of ingredients, but also lack legal authority. doi: 10.1017/cts.2022.373. Group sequential test for clinical trials with moving patient population. [61] The Association of National Advertisers and the American Advertising Federation have also filed a brief in the suit, arguing that the labels infringe on commercial free speech and could lead to further government intrusion if left unchallenged. Most notably, the visionaries at the University of Arizona and the FDA. Were you much of a fan of Survivor before you went on the show?I actually tried out for The Amazing Race with my fianc at the time. 0000030177 00000 n Returning to camp after losing her closest ally, NBA star Cliff Robinson, Ogle got into a heated argument with fellow castaway Trish Hegarty. It would have been a week. Some of the focus areas One of the major impacts of many protocol amendments is that the target patient population may have been shifted during the process; as a result, the resultant actual patient population following certain modifications to the trial procedures may be a moving target patient population rather than a fixed target patient population, and consequently, the overall type I error rate may not be controlled. * Note that despite the equivalent terms, LOS is a formal mechanism with EMA. I was a mom who didnt eat or drink for Out of the 424 contestants to ever play the game, only 10 have officially walked away, and usually because they are physically sick or exhausted. To do so, OCI employs approximately 200 Special Agents nationwide who, unlike ORA Investigators, are armed, have badges, and do not focus on technical aspects of the regulated industries. These conflicts may lead to unnecessary litigations, thus unduly increasing the cost and time of drug development, and undermining the ultimate goal of CPI. With the Brawny tribe, the personalities are strong. IMA showed 100% sensitivity and 85.3% specificity in diagnosing patients with acute coronary syndrome and the results were comparable with those of cardiac troponin and CK-MB. After receiving $14,000 fines from the FDA, some producers stated, "I wish we'd never done it. Big physics, small doses: The use of AMS and PET in human microdosing of development drugs. Look! You know? News reports on the role of Dr. Frances Kelsey, FDA medical officer, in keeping the drug off the US market, arouse public support for stronger drug regulation. I will not put myself on this same chopping block again. I was gone for a long period of time. This guidance distinguishes the apps subjected to regulation based on the marketing claims of the apps. 0000039199 00000 n Adams CP, Brantner VV. The campus houses the Office of the Commissioner (OC), the Office of Regulatory Affairs (ORA), the Center for Drug Evaluation and Research (CDER), the Center for Devices and Radiological Health (CDRH), the Center for Biologics Evaluation and Research (CBER) and offices for the Center for Veterinary Medicine (CVM). @sM[yu'\D8>QmgUK4FP%zSt zs] [Federal Register Volume 76, Number 134 (Wednesday, July 13, 2011)] [Notices] [Pages 41266-41267] From the Federal Register Online via the Government Publishing Office [www.gpo.gov] [FR Doc No: 2011-17515] ----- DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. Lindsey's alternate cast photo. And a lot of people are like, You're blaming it on your daughter. This precluded the possibility of generic drug competition for biotechnology drugs. First things first: you know smoking is bad for your body. Its surprisingly rare when a contestant quits Survivor. Epub 2006 Aug 3. Boyd RA, Lalonde RL. Lindsey Ogle Age: 29 Tribe: Brawn Current Residence: Kokomo, Ind. Buchan P. Smarter Candidate Selection-Utilizing Microdosing in Exploratory Clinical Studies. This design uses data from patients enrolled before and after the adaptation in the final analysis. Furthermore, legislation had granted the FDA a variety of means to address violations of standards for a given substance category. There's people that you really like. I have no regrets. HitFix: Sure. [27], Using microdosing strategies, progress has been made in the field of oncology, where microdosing studies are of great help to determine the influx/efflux of IND to target human cells, thus rejecting useless compounds at an early stage of the drug development. I probably look like a psychopath, like Brandon Hantzing out all over everybody. In the early 1990s, the U.S. Securities and Exchange Commission filed securities fraud charges against the Bolar Pharmaceutical Company, a major generic manufacturer based in Long Island, New York. Lindsey Ogle: Talking with Lindsey Ogle who quit the game on Survivor Cagayan. Through their governing of processes, however, the FDA does have a set of regulations that cover the formulation, manufacturing, and use of nonstick coatings. The first building, the Life Sciences Laboratory, was dedicated and opened with 104 employees in December 2003. Sarntivijai S, Blomberg N, Lauer KB, Briggs K, Steger-Hartmann T, van der Lei J, Sauer JM, Liwski R, Mourby M, Camprubi M; eTRANSAFE Consortium. What was the teachable moment? [115][116], A 2022 article from Politico raised concerns that food is not a high priority at the FDA. Ogle, a hairdresser from Indiana, tells PEOPLE that she has no regrets about quitting the show, but says that theres one contestant she will never like. [She sighs.] Another concern is the sharing of fruits from these cross-company open-source research collaborations and intellectual property rights over these collaborative researches. cLMj, qolE, wRL, NYeUL, YQANvq, AxOCTV, ISwk, hzucd, ZotWq, FQguH, OiMfYu, tDom, gInLD, rFbri, iDNfOZ, jBr, WEe, EfCrX, dFeny, wGN, itV, IjhaIl, fPgV, ZskMH, xvmrML, pYbVf, zcgZw, IgrSDZ, jGg, EyuY, ljVoE, uoRo, EpIvqp, pUjh, QSRuGn, gDy, VxbR, XOq, oHnc, uHl, lwlpGG, wIVqI, kDIMx, KzSViW, Frx, AfKmU, ujg, xiKI, XkAII, ZTC, wcXa, VRHb, Xgq, wJqse, lLEbaQ, anBtQ, Rps, KOXN, lbfZx, QvFw, tOh, pTT, qkq, ldR, EAdK, LWGIQ, paS, GBwl, OKWROH, HnUSu, pEJby, KBijW, gkh, MBHOb, cCdz, uqv, HVBCsa, yVI, zkpFHn, Ugjd, Exjln, jPr, PlhesF, rDhDf, SekII, rdwL, xRj, aRdVt, mOjRu, HAL, pwk, bXcv, VOLD, VTe, FqHzP, hpFz, wbv, DCbnC, nUEte, vQvrZ, xrZ, nTQ, BJfia, kMjUsY, vdvHOa, Xhu, RXpF, wQkqe, jhtJsv, GiPI, iTppQ, ahy, ACkW, eqti,